To ensure effective gas exchange, in addition to uniform ventilation of the lungs, a good blood supply to the ventilated alveoli is necessary. It happens due to both deteriorations of the patency of the bronchi and a change in the extensibility of the lung tissue. With the pathology of the respiratory system, the degree of uneven ventilation of different alveoli increases. Each alveolus has its own characteristics of ventilation and blood flow, so in different parts of the lung, the ratio of ventilation and blood flow is different. Ventilation and perfusion are the main mechanisms that ensure the implementation of the primary function of the lungs – gas exchange. 322 specialists online How can the disease described above create a mismatch between ventilation and perfusion? Use your understanding of alveolar dead space and physiologic shunt to explain your answer
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